Author's response to reviews Title:Acute murine antigen-induced arthritis is not affected by disruption of osteoblastic glucocorticoid signalling Authors:

نویسندگان

  • Cornelia M Spies
  • Edgar Wiebe
  • Jinwen W Tu
  • Aiqing Li
  • Timo Gaber
  • Dörte Huscher
  • Markus J Seibel
  • Frank Buttgereit
  • Gerd-R. Burmester
  • Cornelia M. Spies
  • Jinwen W. Tu
  • Markus J. Seibel
  • Hong Zhou
  • Wim van den Berg
  • Catia Cornacchia
چکیده

Title:Acute murine antigen-induced arthritis is not affected by disruption of osteoblastic glucocorticoid signalling

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Acute murine antigen-induced arthritis is not affected by disruption of osteoblastic glucocorticoid signalling

BACKGROUND The role of endogenous glucocorticoids (GC) in the initiation and maintenance of rheumatoid arthritis (RA) remains unclear. We demonstrated previously that disruption of GC signalling in osteoblasts results in a profound attenuation of K/BxN serum-induced arthritis, a mouse model of RA. To determine whether or not the modulation of the inflammatory response by osteoblasts involves T ...

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Histopathological changes of the antigen-induced chronic arthritis in the knee joint of the rabbit

Background and Objectives: The cause and pathophysiology of rheumatoid arthritis has not been fully understood and an experimental model of this disease is essential for research on the problem. In this research study, establishment and histopathological changes of chronic arthritis due to intra-articula...

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تاریخ انتشار 2013